Scientists Make Embryos From Human Skin DNA For First Time

An anonymous reader quotes a report from the BBC: US scientists have, for the first time, made early-stage human embryos by manipulating DNA taken from people's skin cells and then fertilizing it with sperm. The technique could overcome infertility due to old age or disease, by using almost any cell in the body as the starting point for life. It could even allow same-sex couples to have a genetically related child.

The Oregon Health and Science University research team's technique takes the nucleus -- which houses a copy of the entire genetic code needed to build the body -- out of a skin cell. This is then placed inside a donor egg that has been stripped of its genetic instructions. So far, the technique is like the one used to create Dolly the Sheep -- the world's first cloned mammal -- born back in 1996. However, this egg is not ready to be fertilized by sperm as it already contains a full suite of chromosomes.

You inherit 23 of these bundles of DNA from each of your parents for a total of 46, which the egg already has. So the next stage is to persuade the egg to discard half of its chromosomes in a process the researchers have termed 'mitomeiosis' (the word is a fusion of mitosis and meiosis, the two ways cells divide). The study, published in the journal Nature Communications, showed 82 functional eggs were made. These were fertilized with sperm and some progressed onto the early stages of embryos development. None were developed beyond the six-day-stage.

The technique is far from polished as the egg randomly chooses which chromosomes to discard. It needs to end up with one of each of the 23 types to prevent disease, but ends up with two of some and none of others. There is also a poor success rate (around 9%) and the chromosomes miss an important process where they rearrange their DNA, called crossing over. Prof Mitalipov, a world-renowned pioneer in the field, told me: 'We have to perfect it. 'Eventually, I think that's where the future will go because there are more and more patients that cannot have children.'

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