Four New DNA Letters Double Life's Alphabet

Joe_NoOne (Slashdot reader #48,818) shares this update from Nature: The DNA of life on Earth naturally stores its information in just four key chemicals -- guanine, cytosine, adenine and thymine, commonly referred to as G, C, A and T, respectively. Now scientists have doubled this number of life's building blocks, creating for the first time a synthetic, eight-letter genetic language that seems to store and transcribe information just like natural DNA.

In a study published on 22 February in Science, a consortium of researchers led by Steven Benner, founder of the Foundation for Applied Molecular Evolution in Alachua, Florida, suggests that an expanded genetic alphabet could, in theory, also support life. 'It's a real landmark,' says Floyd Romesberg, a chemical biologist at the Scripps Research Institute in La Jolla, California. The study implies that there is nothing particularly 'magic' or special about those four chemicals that evolved on Earth, says Romesberg. 'That's a conceptual breakthrough,' he adds... Benner says that the work shows that life could potentially be supported by DNA bases with different structures from the four that we know, which could be relevant in the search for signatures of life elsewhere in the Universe...

The researchers call the resulting eight-letter language 'hachimoji' after the Japanese words for 'eight' and 'letter'. The additional bases are each similar in shape to one of the natural four, but have variations in their bonding patterns. The researchers then conducted a series of experiments that showed that their synthetic sequences shares properties with natural DNA that are essential for supporting life... Benner's group previously showed that strands of DNA that included Z and P were better at binding to cancer cells than sequences with just the standard four bases. And Benner has set up a company which commercialises synthetic DNA for use in medical diagnostics.

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