Sugar-Powered Implant Successfully Manages Type 1 Diabetes

Researchers have developed a novel fuel cell implant for type 1 diabetes that can successfully produce and release insulin when triggered. New Atlas reports: The fuel cell itself, which resembles a teabag that's slightly larger than a fingernail, is covered in a nonwoven fabric and coated with alginate, an algae-derived product used widely in biomedicine because of its high degree of biocompatibility. When implanted under the skin, the cell's alginate soaks up body fluid, allowing glucose to permeate the surface and flow into the power center. Inside the cell, the team developed a copper-based nanoparticle anode that splits glucose into gluconic acid and a proton to generate an electric current. 'Many people, especially in the Western industrialized nations, consume more carbohydrates than they need in everyday life,' [Martin Fussenegger from the Department of Biosystems Science and Engineering at ETH Zurich] said. 'This gave us the idea of using this excess metabolic energy to produce electricity to power biomedical devices.

The fuel cell was then coupled with an insulin capsule featuring the team's beta cells, which could be triggered to secrete insulin via electric current from the implant. Overall, the two components provide a self-regulating circuit. When the fuel cell powered by glucose senses excess blood sugar, it powers up. This then stimulates the beta cells to produce and secrete insulin. As blood sugar levels dip, it trips a threshold sensor in the fuel cell, so it powers down, in turn stopping the insulin production and release. This self-sustained circuit could also produce enough power to communicate with a device such as a smartphone, which allows for monitoring and adjusting, and even has potential for remote access for medical intervention. The study was published in the journal Advanced Materials.

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