What Happens After Throughput to DNA Storage Drives Surpasses 2 Gbps?

High-capacity DNA data storage 'is closer than you think,' Slashdot wrote in 2019.

Now IEEE Spectrum brings an update on where we're at — and where we're headed — by a participant in the DNA storage collaboration between Microsoft and the Molecular Information Systems Lab of the Paul G. Allen School of Computer Science and Engineering at the University of Washington. 'Organizations around the world are already taking the first steps toward building a DNA drive that can both write and read DNA data,' while 'funding agencies in the United States, Europe, and Asia are investing in the technology stack required to field commercially relevant devices.'

The challenging part is learning how to get the information into, and back out of, the molecule in an economically viable way... For a DNA drive to compete with today's archival tape drives, it must be able to write about 2 gigabits per second, which at demonstrated DNA data storage densities is about 2 billion bases per second. To put that in context, I estimate that the total global market for synthetic DNA today is no more than about 10 terabases per year, which is the equivalent of about 300,000 bases per second over a year. The entire DNA synthesis industry would need to grow by approximately 4 orders of magnitude just to compete with a single tape drive. Keeping up with the total global demand for storage would require another 8 orders of magnitude of improvement by 2030. But humans have done this kind of scaling up before. Exponential growth in silicon-based technology is how we wound up producing so much data. Similar exponential growth will be fundamental in the transition to DNA storage...
Companies like DNA Script and Molecular Assemblies are commercializing automated systems that use enzymes to synthesize DNA. These techniques are replacing traditional chemical DNA synthesis for some applications in the biotechnology industry... [I]t won't be long before we can combine the two technologies into one functional device: a semiconductor chip that converts digital signals into chemical states (for example, changes in pH), and an enzymatic system that responds to those chemical states by adding specific, individual bases to build a strand of synthetic DNA. The University of Washington and Microsoft team, collaborating with the enzymatic synthesis company Ansa Biotechnologies, recently took the first step toward this device... The path is relatively clear; building a commercially relevant DNA drive is simply a matter of time and money...

At the same time, advances in DNA synthesis for DNA storage will increase access to DNA for other uses, notably in the biotechnology industry, and will thereby expand capabilities to reprogram life. Somewhere down the road, when a DNA drive achieves a throughput of 2 gigabases per second (or 120 gigabases per minute), this box could synthesize the equivalent of about 20 complete human genomes per minute. And when humans combine our improving knowledge of how to construct a genome with access to effectively free synthetic DNA, we will enter a very different world... We'll be able to design microbes to produce chemicals and drugs, as well as plants that can fend off pests or sequester minerals from the environment, such as arsenic, carbon, or gold. At 2 gigabases per second, constructing biological countermeasures against novel pathogens will take a matter of minutes. But so too will constructing the genomes of novel pathogens. Indeed, this flow of information back and forth between the digital and the biological will mean that every security concern from the world of IT will also be introduced into the world of biology...

The future will be built not from DNA as we find it, but from DNA as we will write it.

The article makes an interesting point — that biology labs around the world already order chemically-synthesized ssDNA, 'delivered in lengths of up to several hundred bases,' and sequence DNA molecules up to thousands of bases in length.

'In other words, we already convert digital information to and from DNA, but generally using only sequences that make sense in terms of biology.'

Read more of this story at Slashdot.