The Most-Cited Papers of the Twenty-First Century

Nature has published an analysis of the 21st century's most-cited scientific papers, revealing a surprising pattern: breakthrough discoveries like mRNA vaccines, CRISPR, and gravitational waves don't make the list. Instead, a 2016 Microsoft paper on 'deep residual learning' networks claims the top spot, with citations ranging from 103,756 to 254,074 depending on the database.

The list overwhelmingly features methodology papers and software tools rather than groundbreaking discoveries. AI research dominates with four papers in the top ten, including Google's 2017 'Attention is all you need' paper that underpins modern language models.

The second-most-cited paper -- a 2001 guide for analyzing gene expression data -- was explicitly created to be cited after journal reviewers rejected references to a technical manual. As sociologist Misha Teplitskiy noted, 'Scientists say they value methods, theory and empirical discoveries, but in practice the methods get cited more.'

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