Common Yeast Can Survive Martian Conditions

A new study shows that common baker's yeast (Saccharomyces cerevisiae) can survive Mars-like conditions, including meteorite shock waves and toxic perchlorate salts found in Martian soil. Phys.org reports: Published in PNAS Nexus, Purusharth I. Rajyaguru and colleagues subjected Saccharomyces cerevisiae, which is a widely used model yeast, to shock waves and perchlorates. The authors chose the yeast in part because it has already been studied in space. When stressed, yeast, humans, and many other organisms form ribonucleoprotein (RNP) condensates, structures made of RNA and proteins that protect RNA and affect the fates of mRNAs. When the stressor passes, the RNP condensates, which include subtypes known as stress granules and P-bodies, disassemble.

The authors simulated Martian shock waves at the High-Intensity Shock Tube for Astrochemistry (HISTA) housed in the Physical Research Laboratory in Ahmedabad, India. Yeast exposed to 5.6 Mach intensity shock waves survived with slowed growth, as did yeast subjected to 100 mM sodium salt of perchlorate (NaClO4) -- a concentration similar to that in Martian soils. Yeast cells also survived exposure to the combined stress of shock waves and perchlorate stress. In both cases, the yeast assembled RNP condensates. Shock waves induced the assembly of stress granules and P-bodies; perchlorate caused yeast to make P-bodies but not stress granules. Mutants incapable of assembling RNP condensates were poor at surviving the Martian stress condition. Transcriptome analysis identified specific RNA transcripts perturbed by Mars-like conditions.

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