Sperm Donor With Cancer-Causing Gene Fathered Nearly 200 Children Across Europe

schwit1 shares a report from CBS News: perm from a donor who unknowingly carried a cancer-causing gene has been used to conceive nearly 200 babies across Europe, an investigation by 14 European public service broadcasters, including CBS News' partner network BBC News, has revealed. Some children conceived using the sperm have already died from cancer, and the vast majority of those who inherited the gene will develop cancer in their lifetimes, geneticists said. The man carrying the gene passed screening checks before he became a donor at the European Sperm Bank when he was a student in 2005. His sperm has been used by women trying to conceive for 17 years across multiple countries.

The cancer-causing mutation occurred in the donor's TP53 gene -- which prevents cells in the body from turning cancerous -- before his birth, according to the investigation. It causes Li Fraumeni syndrome, which gives affected people a 90% chance of developing cancers, particularly during childhood, as well as breast cancer in later life. Up to 20% of the donor's sperm contained the mutated TP53 gene. Any children conceived with affected sperm will have the dangerous mutation in every cell of their body. The affected donor sperm was discovered when doctors seeing children with cancers linked to sperm donation raised concerns at this year's European Society of Human Genetics.

At the time, 23 children with the genetic mutation had been discovered, out of 67 children linked to the donor. Ten of those children with the mutation had already been diagnosed with cancer. Freedom of Information requests submitted by journalists across multiple countries revealed at least 197 children were affected, though it is not known how many inherited the genetic mutation. More affected children could be discovered as more data becomes available.

Read more of this story at Slashdot.